Studies on pharmacological activation of human serum immunoglobulin G (IgG) by chemical modification and active subfragments. VI. Anti-allergic activity of carboxamidemethylated Fc (CM-Fc) fragment from human serum IgG.

Coombs and Gell1) classified allergic phenomena into four types, of which three (types I, II and III) are immediate-type, and one (type IV) is delayed-type. The former reactions are caused by humoral antibodies, while the latter is caused by a cellular antibody. We have already reported that the carboxamidemethylated L chain2) and the carboxamidemethylated H and L chains') show anti-ulcerogenic and anti-inflammatory activities, respectively. In this paper, we describe the effect of carboxamidemethylated Fc (CM-Fc) on various allergic models.